Pyrimidine sulphamates

ABSTRACT

Pyrimidine derivatives are provided wherein the 6-position carries the group OSO2NR5R6 and the 2-position carries the group NR1R2. R1 and R2 are preferably hydrogen or lower alkyl but both are not hydrogen and R5 and R6 are preferably lower alkyl, although these groups may form a cyclic ring. The 3-position and 4-position are preferably substituted with lower alkyl, although lower alkynyl or alkenyl may be used. The derivatives are compounded into compositions for combatting fungal pests.

United States Patent 1 Cole et al.

[451 Apr. 29, 1975 1 PYRIMIDINE SULPl-IAMATES [75] Inventors: Ann Mary Cole, Maidenhead; John Angus William Turner, Wokingham; Brian Kenneth Snell, Twyford, all of England [73] Assignee: Imperial Chemical Industries Limited, London, England [22] Filed: Aug. 29, 1972 [211 App]. No.: 284,546

[30] Foreign Application Priority Data Sept. 23. 1971 I United Kingdom 44401 71 52 us. on 260/247. 1 M; 260/250 R; 260/2565 R; 424/248; 424/250;

51 int. Cl. 0 70 87/46; C07d 51/42 [58] Field of Search 260/247.] M, 256.5 "R

[56] References Cited UNITED STATES PATENTS 3,493,574 2/1970 Baranyouits et al. 260/2565 R 3.676.443 7/1972 FORElGN PATENTS OR APPLlCATlONS 1,182,584 2/1970 United Kingdom 260/247.l M

Snell et al. 260/256 R l.l85.039 3/l970 United Kingdom 260/247.l M

OTHER PUBLICATIONS Allinger et al., Organic Chemistry, (1972) pp. 583-584.

Primary Examiner-James A. Patten Assistant Examiner-Michael Shippen Altorney. Agent, or Firm-Cushman, Darby & Cushman [57] ABSTRACT 17 Claims, No Drawings PYRIMIDINE SULPHAMATES This invention relates to new pyrimidine derivatives. to fungicidal compositions containing them and to methods of combating fungal pests using them.

In British Pat. No. 1 185039 there are disclosed and claimed pyrimidine derivatives of the formula:

or a salt thereof, wherein R and R represent atoms or hydrogen, substituted or unsubstituted hydrocarbon groups, or together with the adjacent N-atom form a heterocyclic ring which may contain one or more additional heteroatoms; R, and R represent atoms of hy drogen or halogen, substituted or unsubstituted hydrocarbon groups, or nitro groups; X represents an atom of oxygen or sulphur; and R is a carbonyl or sulphonyl group bearing directly, or through an oxygen or sulphur atom, a substituted or unsubstituted hydrocarbon group, or a heterocyclic group. These compounds are useful fungicides.

1n the aforesaid British Pat. No. 1185039 there are therefore disclosed certain sulphonyl ester derivatives of pyrimidines. Only one sulphamyl ester was specified in that patent, however, having the structure:

11 C11 OSO 'N N(CH This compound does not fall within the narrow class of compounds defined by the present invention and does not possess the same pattern or level of fungicidal activity against powdery mildews.

In British Pat. No. 1 182584 there are disclosed fungicidally active pyrimidine derivatives which are characterised in having a 6-hydroxy group (or a 6-mercapto group) and a 2-amino group present on the pyrimidine ring. These pyrimidine derivatives are highly active fungicides.

None of the compounds specifically disclosed in either of the two aforesaid British Patents, which represent the closest prior art, however, possess a high degree of activity against all the powdery mildews, and against apple powdery mildew Podosphaera leucutricha in particular, as is represented by the class of compounds defined by the present invention.

It has now been found that a narrow class of pyrimidines, some only of which fall within the broad class defined in British Pat. No. 1185039 but not specifically disclosed therein, are particularly broad spectrum fungicides and possess a higher level of activity against powdery mildews, especially against the powdery mildew of apple trees. Pudosphaera Ieucolricha.

Accordingly the present invention provides a pyrimidine sulphamate derivative having the general formula:

lax/Y OSO2NR5R6 and salts thereof, wherein R and R are hydrogen or lower alkyl, lower alkynyl, or lower alkenyl but are not both hydrogen, or together with the adjacent N-atom form a heterocyclic group; R and R are loweralkyl, lower alkynyl, or lower alkenyl;.and R and R" are lower alkyl, lower alkynyl, or lower alkenyl; or together with the adjacent N-atom form a heterocyclic group.

By the terms lower alkyl, lower-alkynyl, and lower alkenyl, are intended groups containing up to 6 carbon atoms. Thus such a group may be a straight or branched chain or cyclic alkyl group. Suitable alkyl groups include, for example, methyl, ethyl, propyl, and butyl, and these may be normal, iso or tertiary groups where appropriate. Suitable alkenyl and alkynyl groups include, for example, allyl, butenyl and propargyl.

Preferred alkyl and alkenyl groups, however, are those containing from 1 to 4 carbon atoms, and from 3 to 4 carbon atoms, respectively, and alkyl groups are preferred. 1

When R and R and R and R together with the adjacent N-atom constitute a heterocyclic group this may comprise any heterocyclic ring, substituted or unsubstituted, for example acridine, isothiazole, pyrrolidine, isoxazole, piperazine, piperidine, aziridine, thiazole, azocine, azepine, pyrrole, pyrazole, imidazole, pyrimidine, indole, pyrazine, quinoxoline and morpholine. Preferred heterocyclic groups, however, coimprise monocyclic rings containing 5-, 6- or 7- ring atoms and preferred substituents thereon include, for example, alkyl groups, for example methyl groups.

In a preferred aspect, therefore, the invention provides a pyrimidine sulphamate derivative having the formula:

NRR

and salts thereof, wherein R and R are hydrogen or lower alkyl, but are not both hydrogen, or together with the adjacent N-atom form a heterocyclic group: R and R are lower alkyl; and R and R are lower alkyl or together with the adjacent N-atom form a monocyclic, 5-, 6- or 7- membered heterocyclic ring, optionally substituted.

Preferred compounds are those wherein R is methyl; R is n-butyl; R and R are hydrogen. allyl. methyl or ethyl but not both hydrogen; and R and R are methyl, ethyl, propyl or butyl or together with the adjacent N- atom form a pyrrole, piperidino, morpholino. piper-azino or azepino ring, optionally substituted with methyl.

In a further aspect, therefore, the invention provides a pyrimidine sulphamate derivative having the formula:

with the adjacent N-atom form a pyrrolidino. morpholino, piperidino, piperazino or azepino ring, optionally substituted with methyl:

In some aspects it is *preferred that R and R are lower alkyl groups, for example methyl, ethyl, propyl and butyl. In some experiments these compounds, especially those wherein R and R were also lower alkyl groups, displayed a slightly higher level of fungicidal activity.

In an even more preferred aspect the invention provides a pyrimidine sulphamate ester having the formula:

| NR R and acid addition salts thereof, wherein R and R are hydrogen. methyl or ethyl but are not both hydrogen;

and R and R are methyl. ethyl, propyl or butyl.

Specific pyrimidine derivatives of the invention which have been found to be particularly useful are listed in the Table 1 below. The headings to the columns of the table correspond to the substituent groups on the pyrimidine ring in the general formula:

3 5 CH (OSO NR R R /OSO2NR R l i I I D NYN NR1R2 NR1R2 TABLE 1 Compound No: R1 R2 R3 R R5 R6 Melting Point 1 CH cu on gC H CH3 ca 011 3 CH CH3 CH3 1-1 011 "N 3 cu CH3 ca c n L1 011 1 l 4 CH3 0A CH3 0 .1 1 011 l N/"' o 5 h C rl CH3 r 1CuH9 J 72 c 1 o 6 H CH3 cs no n 41C) 11 1 c 7 H 0 1-1 CH3 0 11 c n 2 0. 11 011 8 H c 11 ca c a c 11 0 11 011 o 9 c 11 c 11 CH3 c n L] 7 C O 10 H p n ch C h G 56 c 3 60C 11 H 0 11 on 0, 11 (3 e I o 12 CH5 c a U 88 c Compound R R R V R R R Melting. Point i 13 H Lise- Jil CH3 QCMH9 O11 -r 17 19 11 c 11, 011 0 ,11 lsoc h lscc n Oil O 1 15 H IC H CPI n C -l CH CH 1 16 H I c 11, 011 11-0,,11 isoC3H7i C3li7 Oil 17 H C H 0H nC l-l U 3 76-77 C 8 u H l H 0 5 CH nC H nC H nC I-l 011 19 11 0 11 cu 110 11 ]7ring Oil 2o 11 c 11 11 c H 2 5 u 3 n u 9 102 103 1 f 21 H C 1 1 CH nC l-l --CH 02.1

22 H c H i 2 5 CH nC H Cl-l nC i'l O11 23 H 1 0 11 (:11 60 ,11 -1\ o mpt M 1 2 H C 11 CH 110 1-1 CH 0 1-1 011 p o 25 11 4211 011015511 1S0 0, 11 01-1 011 1 o 26 11 -c1 011015011 cn cu pr on 011 2 mt 62.6 1 27 H 01% cnm cu 01% 011 (:11 p

For compounds recorded as oils in Table I elemen- Compounds Nos. 1, 3, 5, 8, l l and 15 are particularly tal analyses were carried out. The results are as follows: useful fungicides.

COm- The invention, therefore, includes, as new com- Pmmd Requimd Fmmd pounds, each and every specific pyrimidine sulphamate C H N C H N derivative set out in Table 1 above, and in particular.

1 49.35 7.59 17.73 49.111 6.96 17.112 Compound Nos. 1, 3. 5, 8, 11 and 15. 2 5393 -1 2-32 in this specification the numbering of the pyrim1dme is 716 i7? 4X0 7137 17.5 ring is as followsi 111 54.5 11.60 15.06 55.02 11.60 14.5 19 55.1 11.1 4 15.14 53.2 I p 5 22 53.60 11.311 15.64 53.. p 23 50.30 7.26 15.64 51.10 7.34 16.00 24 50.93 7.1111 16.911 50.1111 769 16.70 Y 4 50.30 7.26 15.64 49.95 7.41 15.25 Y 7 I I i 7 57.00 9.00 14.00 56.35 11.91 13.57 w 14 57.00 9.00 14.00 56.92 9.30 13.61 16 54.110 11.60 15.06 54.94 11.59 14.62 v 25 51.20 7.37 17.06 50.60 7.011 16.99 I I 26 49.911 6.45 17.93 49.34 6.29 17.59 11 may be noted that the 4- and 6- positions are equiva- 27 50.30 5.114 111.05 49.14 5.57 17.95 lent.

The pyrimidine sulphamate derivatives of the invention may be made by reacting the appropriate 6- hydroxypyrimidine with the appropriate sulphamoyl chloride. The o-hydroxypyrimidine may be prepared by any of the methods set out in the literature and in British Pat. No. I 182584 and British Pat. application No. 33079/72. The o-hydroxypyrimidine is treated with alkali metal hydroxide, for example sodium hydroxide, in an organic liquid, for example toluene, benzene, xylene or ethyl acetate and the water removed by subjecting the mixture to reflux. Having thus formed the sodium salt of the pyrimidine, the sulphamoyl chloride is added and heating under reflux continued, The reaction mixture is then extracted with caustic, for example with 10% NaOH, to remove unchanged 6- hydroxypyrimidine and then washed with water until neutral washings (to litmus) are obtained. A recrystallisation, or other purification procedure, may then be carried out if necessary, or if desired.

As an alternative to the above procedure, the 6- hydroxypyrimidine may be reacted with alkali metal or sodium methoxide or ethoxide in methanol or ethanol, thereafter removing the alcohol used as solvent and adding the sulphamoyl chloride. Thereafter the reaction is carried forward as described above.

Molar proportions of reactants are preferably used.

As suitable salts of the pyrimidine derivatives of this invention there may be mentioned. for example, the hydrochlorides. Other salts include the salts of the pyrimidine derivatives with organic acids, for example, acetates, picrates, and the like. These salts may be prepared quite readily, in the usual way, by adding the appropriate acid to the pyrimidine sulphamate.

The compounds of the invention are, as previously mentioned. active fungicides, particularly useful against the diseases:

Sphaerotlzet'a fuligineu (powdery mildew) on cucumber Pudosphuera Ieucostriclza (powdery mildew) on apple Um'inula nec'alor (powdery mildew) on vine Erysiplie graminis (powdery mildew) on barley Erysiphe graminis (powdery mildew) on wheat The compounds may be used as such for anti-fungal purposes but are more conveniently formulated into compositions for such usage.

In a further aspect, therefore, this invention provides a fungicidal composition comprising as an active ingredient a pyrimidine sulphamate having the formula:

oso NR5R6 NR R In a preferred aspect the invention provides a fungicidal composition comprising, as an active ingredient. a pyrimidine sulphamate derivative having the formula:

oso NR5R6 or a salt thereof, wherein R and R are hydrogen,

methyl, ethyl, or allyl, but are not both hydrogen; and R and R are methyl, ethyl, propyl or butyl or together with the adjacent N-atom form a pyrrolidino, morpholino, piperidino, piperazino or azepino ring, optionally substituted with methyl; and a carrier for the active ingredient.

More particularly, in an especially preferred aspect, the invention provides a fungicidal composition comprising, as an active ingredient a pyrimidine sulphamate ester having the formula:

G i-I OSO NRR or an acid addition salt thereof, wherein R and R are hydrogen, methyl or ethyl but are not both hydrogen; and R and R are methyl, ethyl, propyl or butyl; and a carrier for the active ingredient.

The invention compounds and compositions containing them, are, as stated above, useful for combating fungal diseases.

In a further aspect, therefore, the invention includes a method for combating fungi which comprises treating plants. seeds'or trees with a pyrimidine sulpharn'ate derivative ash'ereinbe'fo re de finedin; any of the preceding paragraphs, or a composition'containing said pyrimidine derivatives a'dfiiid' in any of'the preceding paragraphs or hereinafter.

The active pyrimidine sulphamate derivatives of this invention, and compositions containing them, can be used to combat plant fungi and treat plants or seeds in a number of ways. Thus they can be applied. formulated or unformulated, directly to the foliage of a plant which is infected or likely to become infected. They can be applied 'also to bushes and trees, to seeds or to other propagative parts of plants, or to soil or other medium in which plants. bushes or trees are growing or to be planted. They can be sprayed on, dusted on or applied as a cream or paste formulation. Application can be to any part of the plant, bush or tree for example to the foliage, stems, branches or roots. All these modes of applicationare deemed to fall with the scope of the term treating" used in this specification and claims, and the word plant is to be taken to include seedlings, bushes and trees. Furthermore, as is evident from the foregoing, the invention includes preventative, protectant, prophylactic and eradicant treatment.

The pyrimidine derivatives of this invention are preferably used in the form of compositions and these compositions may be used for agricultural and horticultural purposes. The type of composition used in any instance will depend upon the particular purpose for which it is to be used.

with a solid diluent or carrier. Suitable solid diluents or carriers may be, for example, kaolin, bentonite, kiesel guhr, dolomite, calcium carbonate, talc, powdered magnesia, Fullers earth, gypsum, Hewitts earth, diatomaceous earth and China clay. Compositions for dressing seed, for example, may comprise an agent assisting the adhesion of the composition to the seed, for example a mineral oil.

The compositions may also be in the form of dispersible powders or grains comprising, inaddition to the active ingredient, a wetting agent to facilitate the dispersion of the powder or grains in liquids." Such powders o'r grains may include fillers, suspending agents and the like. a

The aqueous dispersions or emulsions'may be prepared by dissolving the active ingredient or ingredients in an organic solvent which may contain one or more wetting, dispersing or emulsifying agents and then add- 7 ing the mixture so obtained to water which may likewise contain one or more wetting, dispersing or emulsifying agents. Suitable organic solvents are ethylene dichloride, isopropyl alcohol, propylene glycol, diacetone alcohol, toluene, kerosene, methylnaphthalene, xylenes and trichloroethylene.

The compositions to be used as sprays may also be in the form of aerosols wherein the formulation is held in a container under pressure in the presence of a propellant such as fluorotrichloromethane or dichlorodifluoromethane. By the inclusion ,of suitable additives. for example for improving the distribution;adhesivepower and resistance to rain ontreated surfaces, the different compositions can be better adapted for thewarious uses for which they are intended. l

:The pyrimidine derivatives may also be conveniently formulated by admixing them with fertilizers. A preferred composition of this type comprises granules of fertilizer material incorporating, for example coated with, a pyrimidine derivative. The fertilizer material may, 'for example, comprise nitrogen or phosphatecontaining substances.

In yet a further aspect of the invention, therefore. we provide a fertilizer composition comprising a pyrimidine derivative as hereinbefore defined.

The compositions may also be in the form of liquid preparations to be used as dips or sprays which are generally aqueous dispersions or emulsions containing the active ingredient in the presence of one or more wetting agents, dispersing agents, emulsifying agents or suspending agents.

Wetting agents, dispersing agents and emulsifying agents may be of the cationic, anionic or non-ionic type. Suitable agents of the cationic type include, for example, quaternary ammonium compounds, for example, cetyltrimethylammonium bromide. Suitable agents of the anionic type include, for example, soaps, salts of aliphatic monoesters of sulphuric acid, for example sodium lauryl sulphate, salts of sulphonated aromatic compounds, for example sodium dodecylbenzenesulphonate. sodiumycalcium or ammonium lignosulphonate. butylnaphthalene sulphonate. and a mixture of the sodium salts of diisopropyland triisopropylnaphthalene sulphonic acids. Suitable agents of the non-ionic type include, for example, the condensation products of ethylene oxide with fatty alcohols such as oleyl alcohol or cetyl alcohol, or with alkyl phenols such as octylphenol, nonylphenol and octylcresol.

-Othe r non-ionic agents are the partial esters derived from long chain fatty acids and hexitol anhydrides, the condensation products of the said partial esters with ethylene oxide, and the lecithins.

Suitable suspending agents are, for example, hydrophilic colloids, for example polyvinylpyrrolidone and sodium carboxymethylcellulose, and the vegetable gums, for example gum acacia and gum tragacanth.

The compositions which are to be used in the form of aqueous dispersions of emulsions are generally supplied in the form of a concentrate containing a high proportion of the active ingredient or ingredients, the said concentrate to be diluted with water before use. These concentates are often required to withstand storage for prolonged periods and after such storage to be capable of dilution with water in order to form aqueous preparations which remain homogeneous for a sufficient time to enable them to be applied by conventional spray equipment. The concentrates may conveniently contain from about 10-85% by weight of the active ingredient or ingredients and generally from about 25-60% by weight ofthe active ingredient or ingredients. When diluted to form aqueous preparations, such preparations may contain varying amounts of the active ingredient or ingredients depending upon the purpose for which they are to be used, but an aqueous preparation containing from between 0.001 and 0.0l% up to approximately 10% by weight of active ingredient or ingredients may be used. It is to be understood that the biologically active compositions of this invention may comprise. in addition to a pyrimidine derivative, one or more other com- 'pounds having biological activity. They may also incor- EXAMPLE 1 This example illustates the preparation of S-n-butyl- 2-dimethylamino-6-methyl-4-pyrimidinyll -pyrrolidine sulphonate. having the formula:

.. C I-1 m) 3 2 (Compound No.5 of

Table I) To a solution of sodium ethoxide, prepared by dissolving sodium (43.3 g) in ethanol (1340 ml.) was added 5-n-butyl-2-dimethy1amino-4-hydroxy-6- methylpyrimidine (392.1 g). The ethanol was then removed by distillation and replaced by dry ethyl acetate, part of which was distilled off to remove the last traces of ethanol. To the resultant mixture l-pyrrolidine sulphonyl chloride (300 g) was added and the mixture refluxed for several hours. After cooling and filtering off the insoluble portion, the filtrate was washed with 5% sodium hydroxide solution and then with water until neutral washings were obtained.

After drying over anhydrous sodium sulphate the volatile fraction was removed by evaporation under reduced pressure, last traces of solvent being removed by heating to 80C under high vacuum. The residual undistillable oil is 5-n-butyl-2-dimethylamino-6-methyl-4- pyrimidinyl-l-pyrrolidine sulphonate.

Compounds Nos. 2, 4, 9, 11, 12, 17, 19, 20, 21 and 23 were prepared in an analogous manner using the appropriate reactants.

EXAMPLE 2 By a similar procedure to that illustrated in Example' (Compound No.5 of

Table I) EXAMPLE 3 In a similar experiment to that illustrated in Example 1, but using the appropriate reactants. and also using Toluene to assist in the removal of the last ethanol traces before adding the ethyl acetate. there was obtained 5-n-butyl-2-n-propylamino-6-methyl-4- pyrimidinyl-l-pyrrolidine sulphonate having the formula:

OSO -N l (Compound No.11 V of Table I) NHC H (n) I EXAMPLE 4 This example illustrates the preparation of the compound having the structure:

Sodium (1.15 g) was dissolved in ethanol ccs) and the pyrimidine, 2-pyrollidine-4-methyl-5-nbutyl-6- hydroxypyrimidine (11.77 g., 0.05M), added and allowed to dissolve. The solution was then evaporated to dryness. The resulting solid was suspended in benzene and l-pyrollidine sulphonyl chloride (8.48 g., 0.05M) added. The mixture was then heated under reflux for 2V2 hours, allowed to cool and filtered. The filtrate was then washed with water, 10% sodium hydroxide solution and then with portions of water, until the washings gave a neutral reaction. The product was then dried over magnesium sulphate, the magnesium sulphate filtered off and the solution stripped to dryness. Yield of product 10.79 g. (58.6%), melting point 88C.

EXAMPLE 5 This example illustrates the preparation of the compound having the formula:

(Compound No. 11 of Table l) nC H CH 1 O-SQ' l(Cll (Compound No. 15

ofTable l) 2-ethylamino-4-methyl-5 n-butyl-6-hydroxypyrimidine (32.1 g; 0.1 1M), and sodium hydroxide (4.0 g; 0.1M) were mixed in toluene 300 ml) and the mixture heated under reflux to remove the water formed during the preparation of the sodium salt of the 6-hydroxy pyrimidine. Dimethylsulphamoyl chloride (14.35 g; 0.1M) in toluene (40 ml) was added and the whole mixture was heated under reflux for 3 /2 hours, and then cooled. The solution was washed three times with sodium hydroxide solution (200 ml. of a 10% solution) and then twice with water (200 ml). The solution was then dried with anhydrous magnesium sulphate and the toluene distilled off to yield a dark brown oil, yield 22.15 g. (70%) refractive index 11,, 1.5146.

The compounds numbered 1,7, 8,14, 15, 16,18, 22 and 24 in Table I were prepared in an exactly analogous manner using the appropriate substituted pyrimidine and the appropriately substituted sulphamoyl chloride.

EXAMPLE 6 An emulsifiable concentrate was made up by mixing together the ingredients set out below in the proportions stated an stirring the mixture until all the constituents were dissolved.

Compound No. of Table I 10% Ethylene Dichloride 40% Calcium dodecylbenzenesulphonate Lubrol L AromasoF' H 35% EXAMPLE 7 A composition in the form of grains readily dispersible in a liquid, e.g. water, was prepared by grinding together the first three of the ingredients listed below in the presence of added water and then mixing in the sodium acetate. The resultant mixture was dried and passed through a British Standard mesh sieve. size 44-100, to obtain the desired size of grains.

Compound No, 50% Dispersol T 25% Lubrol" APN 5 1.5% Sodium Acetate 23.5%

EXAMPLE 8 The ingredients listed below were all ground together in the proportions stated to produce a powder formulation readily dispersible in liquids.

Compound No. 45% Dispersol" T 5% Lissapor NX 0.5% "Cellofas" B600 2% Sodium acetate 475% EXAMPLE 9 The active ingredient (Compound No. of Table l) was dissolved in a solvent and the resultant liquid was sprayed on to the granules of Fullers earth. The solvent was then allowed to evaporateto produce a granular composition.

Compound No. 5% Fullers earth or China clay granules 95% EXAMPLE 10 A composition suitable for use as a seed dressing was prepared by mixing all three of the substituents set out 10 below in the proportions stated.

Compound No. 50% Mineral Oil 2% China Clay 48% EXAM PLE 1 1 A dusting powder was prepared by mixing, in the proportions stated, the active ingredient with talc.

Compound No. 5% 'Talc 95% EXAMPLE 12 A Col formulation was prepared'by ball-milling the constituents set out below and then forming an aqueous suspension of the ground mixture with water.

3 5 Compound No. 40% Dispersol" 10% Lubrol" 1% Water EXAMPLE 13 A dispersible powder formulation was made by mixing together the ingredients set out below and then grinding the mixture until all the constituents were thoroughly mixed.

Compound No. 3 of Table l Exactly the same formulation was made using Compound No. 15 of Table 1.

EXAMPLE 15 The ingredients set out below were formulated into a dispersible powder by mixing and grinding the ingredients in the proportions stated.

Compound No. 5 of Table 25% AEROSOL" OT/B 2% Dispersol" A 5% China Clay 68% LUBROL" L is a condensate of l mole of nonyl phenol with 1.3 molar proportions of ethylene oxide.

"AROMASOL H is a solvent mixture of alkylbenzenes DISPERSOL" is a mixture of sodium sulphate and a T and AC condensate of formaldehyde with the sodium salt of naphthalene sulphonic acid.

is a condensate of l mole of nonyl phenol with 5 moles of naphthalene oxide.

is a sodium carboxymethyl cellulose thickener.

is a condensate of l mole of nonyl phenol with 8 moles of ethylene oxide.

is dioctyl sodium sulphosuccinate.

is an alkyl naphthalene sulphonate (sodium salt) LUBROL APN 5 CELLOFAS B 600 LISSAPOU NX AEROLSOL" OT/B PERMINAL" BX EXAMPLE 16 The compounds of this invention were tested against a variety of foliar fungal diseases of plants. The technique employed is to spray foliage of the undiseased plants with a solution of the test compound. All solutions for spraying and drenching contained 100, 25, I0, 5 and 1 parts per million of the test compound. The plants were then infected with the diseases it was desired to control and after a period of days, depending upon the particular disease. the extent of the disease was visually assessed. The results are given in Tables 2A and 28 below. wherein the extent of the disease is given in the form of a grading as follows:

Grading Percentage Amount of Disease 61 to l()() l 26 to (it) 2 6 to 25 3 (l to 5 In Table 2 the disease is given in the first column, and in the second column is given the time which elapsed between infecting the plants. and assessing the amount of disease.

TABLE 2 Disease and Plant Time Interval Disease Code (days) Letter (Table 2A) (Vine) Erysip/ugruminis B (Wheat) Ieucolrit'ltu (Apple) Splmermlrccu D fuliginea (Cucumber) TABLE 2A (100 ppm) Compound No. Disease Code Letter (Table l) A B C D l 3 3 3 3 2 3 l 3 3 3 3 3 3 3 4 3 (l 3 3 5 3 3 3 3 6 3 2 3 3 7 (l 3 8 3 3 3 9 3 3 3 3 l0 3 3 3 3 l l 3 3 3 3 l2 3 3 3 3 l3 3 3 3 3 l4 3 0 3 3 l5 2 3 3 lo 1 3 3 l7 0 2 3 l8 3 3 3 I) o 3 3 20 2 3 3 2] (l l 3 22 2 3 3 23 3 3 3 24 3 3 3 means not tested.

The above results clearly show that the invention compounds are active against a range of powdery mildews.

In Table 28 below even lower rates of application (ppm parts per million) are used and a comparison is made with earlier pyrimidine fungicides which themselves are firmly established commercial products (fungicides).

TABLE 28 (25. 10, 5 and 1 ppm) Compound Rate of DISEASE No. Application Apple Vine Cucumber (ppm Powdery Powdery Powdery Mildew Mildew Mildew 9 25 3 3 3 l0 3 O 3 5 l (l 3 l l 25 3 3 3 l0 3 3 3 5 3 l 3 I0 25 3 3 3 l0 3 3 3 5 l l 3 4 25 3 l 3 ll) 5 3 3 3 l 3 2 Z 6 25 3 0 3 l0 2 0 3 5 2 O 2 g 25 3 3 3 l0 3 O 3 3 3 17 TABLE 2B,(25.. l0. S and l ppm)-Continued The above results clearly show the invention compounds to be more widely active. i.e. active against a Compound Rate of" i i DISEASE NO. Applicmion Apple vine Cucumber wider range of powdery mildews at lower rates of appli- (ppm) Powder Powdery Powdery cation. than the already excellent and commercially Mildew M'ldew well-known pyrimidine fungicides of British Pat. No. Dimethiri- 25 2 (l 3 1 182584 mol* 3 5 l 0 3 l O l Ethiri- 3 0 3 EXAMPLE l7 7 Q 0 O 5 m The improvement which the fungicidal compounds 1 0 1 of the present invention represent over other well- 3 I 2 established commercial products are demonstrated in 5 I; a series of comparative tests described below. 4 I In these tests the following commercial products are 5 g 3 i 15 referred to:

Common Name Trade Name Formula DINOCAP "CROTOTHANE" See Page 192 of n "KARATHANE" I the P'e'StlClde Manual second edition by Hubert Martin (1971) and published by the 1 British Crop Protection Council.

BENOMYL "BENLATE" See Page 3 1 of the "Pesticide Manual" second edition by Hubert Martin (1971) and published by the British Crop Protection Council.

.CELA 52 i W HOCHNHIN Cl-lNHCOl-I CCl CCl 13 3 A series of field trials were carried out comparing the 5 I g I v I invention compounds with well-known commercial l5 3 55 products used for combating apple powdery mildew.

5 3 l l 1s 35 3 o 3 In each instance young fruiting apple trees were high 2 T U 6 volume sprayed (i.e. above the rate of 100 litres per 30 2; 3 3 3 hectare) to the point of run-off (that is until the leaves I0 were well wetted and the spray fluid just started to run 22 :2 3 off the leaves). at approximately fortnightly intervals 10 from bud burst until extension growth ceased in the 23 :2 Autumn (normally 9-10 sprays per season) with a for- 10 mulation containing an invention compound. The trees ,2 2 Q g were periodically assessed for mildew control by visual ii) a l L inspection of the leaves after the first appearance of *Dimclhiriniol and Ethirimul are compounds Nos. 4 and 3t! rcspuctiwl of'l'ahlc mildew. Both primary and secondary mildew were observed.

TRIAL SERIES NO. I (U K 1972) Primary Mildew Sporulation (7! disease control) Dispersiblu Powder Formulations "Emulsiliablc Concentrate Formulations.

Secondary Mildew (Percentage Mildew Control) Rate Compound of ASSESSMENT DATE Appli- 1 st 2nd 3rd cation (15.6.72) (4.7.72) 7.7.72)

' DlNOCAP 300 46.4 I84 1 L6 5* (Table l) 250 65.l 29.4 11.0 500 54.0 45.0 44.6 I 1* 250 52.7 45.4 36.8 500 59.4 49.0 50." 5** 250 6l.() 57.8 49.0 500 83.6 75.9 72.0 BENOMYL 250 59.5 47.3 48.0 CELA 524W 250 78.0 71.3 43.4

'Dispersihlc Powder Formulations "Emulsifiablc Concentrate Formulations The above results clearly show the superiority of the invention compounds over certain well-known products for Combating Podosplzaera Ieucolricha (apple powdery mildew) and their at least equal, or in some instances better, performance compared with the very best known commercially available apple mildew fungicides (for example Benomyl or BENLATE) TRIAL NO. 2

(a) Variety: Golden Delicious. (U.K. I972) Compound 71 Number of leaves with Rate of Secondary Mildew Application DINOCAP 19.3 300 ppm No. 5* 16.4 250 ppm No. 8* 15.0 250 ppm No.l5* x.4 250 ppm (b) Variety: Cox's orange Pippin (U.K. l972) Compound 7( Number of leaves Rate of with Secondary Mildew Application DlNOCAP l3.2 300 ppm No. 5* 7.4 250 ppm No. 8* H5 250 ppm No. |5* 4.0 250 ppm Dispcrsiblc Powder l-ormulations TRlAL SERIES NO. 3 (U.K. 1971) Intensity of Sporulation of Mildew on Primary Mildew Rosettes Control 0 Secondary Mildew Compound Rate of Application "/1 Mildew Control DlNOCAP 300 38 BENOMYL 250 59 No. 3* (Table l) 250 46 No. l 1* (Table l) 250 59 No. 5* 250 51 No. 5 250 66 Control 0 Dispersiblc powder formulations. "Contained additional AGRAL wetter.

TRIAL NO. 4 (Spain 1972) Compound Percentage Number of Leaves with Secondary Mildew.

lst 2nd 3rd DlNOCAP 9.1 21.3 l3.3

No. 5* (Table l) I34 27.] 19.5

No. 8 6.5 l6.9 14.0

No. l5* 3.4 8.] 5.7

'Dispersiblc Powder Formulations.

We claim: 1. A pyrimidine sulphamate derivative having the formula:

l NR R or a salt thereof. wherein R and R are hydrogen or lower alkyl, lower alkynyl or lower alkenyl but are not both hydrogen. or together with the adjacent N-atom form a monocyclic 5-. 6- or 7-ring atom heterocyclic group. optionally interrupted by an additional hetero atom selected from the group consisting of O, N and S; R and R are lower alkyl, lower alkynyl or lower alkenyl: and R and R are lower alkyl. lower alkynyl or lower alkenyl or together with the adjacent N-atom form a monocyclic 5-, 6- or 7-ring atom heterocyclic group. optionally interrupted by an additional hetero atom selected from the group consisting of O. N and S.

2. A pyrimidine sulphamate of claim 1 having the formula:

NR R

or a salt thereof, wherein R and R are hydrogen. methyl. ethyl. or allyl. but are not both hydrogen; and

R and R are methyl, ethyl, propyl or butyl or together with the adjacent N-atom form a pyrrolidino, morpholino, piperidino, piperazino or azepino ring, optionally substituted with methyl.

3. A pyrimidine sulphamate according to claim 1 wherein R and R are lower alkyl, lower alkynyl or lower alkenyl.

4. A pyrimidine sulphamate according to claim 3 wherein R and R are hydrogen or lower alkyl, lower alkynyl or lower alkenyl but are not both hydrogen.

5. A pyrimidine sulphamate according to claim 4 wherein R and R are hydrogen, methyl. ethyl, or allyl, but are not both hydrogen; and R and R are methyl, ethyl, propyl or butyl.

6. A pyrimidine sulphamate according to claim 5 wherein R is hydrogen, R is ethyl, R is methyl, R is n-butyl, R is methyl and R is methyl.

7. A pyrimidine sulphamate according to claim 1 wherein the alkyl and alkenyl groups contain from 1 to 4 carbon atoms, and from 3 to 4 carbon atoms, respectively.

8. A pyrimidine sulphamate according to claim 7 wherein the alkyl groups are methyl, ethyl, propyl or butyl and the alkenyl groups are allyl or butenyl.

9. A pyrimidine sulphamate according to claim 1 wherein the heterocyclic groups are selected from pyrrolidino, morpholino, piperidino, piperazino or azepino rings.

10. A pyrimidine sulphamate according to claim I wherein R,, R and R are methyl, R is n-butyl and R and R form piperidino.

11. A pyrimidine sulphamate according to claim 1 wherein R,, R and R are methyl, R is n-butyl and R and R, form pyrrolydino.

12. A pyrimidine sulphamate according to claim 1 wherein R R and R are methylfR, is n-butyl and R and R. form morpholino.

13. A pyrimidine sulphamate according to claim 1 wherein R is hydrogen, R is ethyl, R is methyl. R is n-butyl and R and R form pyrrolidino.

14. A pyrimidine sulphamate according to claim 1 wherein R. is hydrogen, R is ethyl, R is methyl, R is n-butyl and R and R are both ethyl.

15. A pyrimidine sulphamate according to claim 1 wherein R is hydrogen, R is n-propyl, R is methyl, R is n-butyl and R and R form pyrrolidino.

16. A pyrimidine sulphamate according to claim 1 wherein R is hydrogen, R is iso-propyl, R is methyl, R is n-butyl and R and R form pyrrolidino.

17. A pyrimidine sulphamate according to claim 1 wherein R and R are hydrogen or lower alkyl, and R R R and R are lower alkyl, 

1. A PYRIMIDINE SULPHAMATE DDRIVATIVE HAVING THE FORMULA:
 2. A pyrimidine sulphamate of claim 1 having the formula:
 3. A pyrimidine sulphamate according to claim 1 wherein R5 and R6 are lower alkyl, lower alkynyl or lower alkenyl.
 4. A pyrimidine sulphamate according to claim 3 wherein R1 and R2 are hydrogen or lower alkyl, lower alkynyl or lower alkenyl but are not both hydrogen.
 5. A pyrimidine sulphamate according to claim 4 wherein R1 and R2 are hydrogen, methyl, ethyl, or allyl, but are not both hydrogen; and R5 and R6 are methyl, ethyl, propyl or butyl.
 6. A pyrimidine sulphamate according to claim 5 wherein R1 is hydrogen, R2 is ethyl, R3 is methyl, R4 is n-butyl, R5 is methyl and R6 is methyl.
 7. A pyrimidine sulphamate according to claim 1 wherein the alkyl and alkenyl groups contain from 1 to 4 carbon atoms, and from 3 to 4 carbon atoms, respectively.
 8. A pyrimidine sulphamate according to claim 7 wherein the alkyl groups are methyl, ethyl, propyl or butyl and the alkenyl groups are allyl or butenyl.
 9. A pyrimidine sulphamate according to claim 1 wherein the heterocyclic groups are selected from pyrrolidino, morpholino, piperidino, piperazino or azepino rings.
 10. A pyrimidine sulphamate according to claim 1 wherein R1, R2 and R3 are methyl, R4 is n-butyl and R5 and R6 form piperidino.
 11. A pyrimidine sulphamate according to claim 1 wherein R1, R2 and R3 are methyl, R4 is n-butyl and R5 and R6 form pyrrolydino.
 12. A pyrimidine sulphamate according to claim 1 wherein R1, R2 and R3 are methyl, R4 is n-butyl and R5 and R6 form morpholino.
 13. A pyrimidine sulphamate according to claim 1 wherein R1 is hydrogen, R2 is ethyl, R3 is methyl, R4 is n-butyl and R5 and R6 form ppyrrolidino.
 14. A pyrimidine sulphamate according to claim 1 wherein R1 is hydrogen, R2 is ethyl, R3 is methyl, R4 is n-butyl and R5 and R6 are both ethyl.
 15. A pyrimidine sulphamate according to claim 1 wherein R1 is hydrogen, R2 is n-propyl, R3 is methyl, R4 is n-butyl and R5 and R6 form pyrrolidino.
 16. A pyrimidine sulphamate according to claim 1 wherein R1 is hydrogen, R2 is iso-propyl, R3 is methyl, R4 is n-butyl and R5 and R6 form pyrrolidino.
 17. A pyrimidine sulphamate according to claim 1 wherein R1 and R2 are hydrogen or lower alkyl, and R3, R4, R5 and R6 are lower alkyl. 